Neurobiology of Disease Interferon- Is a Critical Modulator of CB2 Cannabinoid Receptor Signaling during Neuropathic Pain
نویسندگان
چکیده
Ildiko Racz,1* Xavier Nadal,3* Judith Alferink,1,2* Josep E. Baños,3 Jennifer Rehnelt,1 Miquel Martín,3 Belén Pintado,5 Alfonso Gutierrez-Adan,5 Elena Sanguino,6 Nicolas Bellora,4 Jorge Manzanares,6 Andreas Zimmer,1 and Rafael Maldonado3 1Institute of Molecular Psychiatry and 2Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, 3Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, and 4Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, 08003 Barcelona, Spain, 5Departamento de Reproducción Animal y Conservación de Recursos Zoogenéticos, Instituto Nacional de Investigación y Tecnología Agraria, 28040 Madrid, Spain, and 6Instituto de Neurociencias de Alicante, Universidad Miguel Hernández–Consejo Superior de Investigaciones Científicas, 03550 Alicante, Spain
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Spinal Cord is the Primary Site of Action of the Cannabinoid CB2 Receptor Agonist JWH133 that Suppresses Neuropathic Pain: Possible Involvement of Microglia
Neuropathic pain, a highly debilitating condition that commonly occurs after damage to the nervous system, is often resistant to commonly used analgesic agents such as non-steroidal anti-inflammatory drugs and even opioids. Several studies using rodent models reported that cannabinoid CB2 receptor (CB2R) agonists are effective for treating chronic pain. However, the analgesic mechanism of CB2R ...
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